pentobarbital will reduce the extent or impact of artemether/lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with sturdy CYP3A4 inducers can result in diminished serum concentrations and loss of antimalarial efficacyJust after halting a CYP3A4 inducer, because the effects from t